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In response, the damaged and dying neurons release damage-associated molecular patterns (DAMPs), adenosine triphosphate (ATP), cell debris, neuroinflammatory cytokines, and microglial activators, further activating microglia and continuing the inflammatory cycle (80, 109) (Figure 2H)
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Emergency department evaluation typically includes laboratory testing (complete blood count, comprehensive metabolic panel, liver function tests) and imaging, most commonly right upper quadrant ultrasound, which is the first-line imaging modality according to American College of Radiology Appropriateness Criteria